Endocrine Abstracts

Introduction: Hypogonadism is linked to anaemia, sarcopenia and osteoporosis in men. Whereas secondary hypogonadism (SH) is biochemically indistinguishable from nongonadal illness, primary hypogonadism (PH) can be easily diagnosable by the identification of raised gonadotropins.Case Presentation: A 66-years old male with a background history of type 2 diabetes mellitus, arthritis, and hypertension was referred to the haematology services to investigate h...

Background: Functional hypogonadotrophic hypogonadism (FHH) occurs in the context of any chronic disease including obese patients with type 2 diabetes (T2DM) and/or metabolic syndrome. FHH is reversible with resolution of the underlying disease process. Reported benefits of bariatric surgery include improvements in lipid profile, blood pressure and resolution of T2DM. Here we report reversal of FHH and T2DM with bariatric surgery-associated weight loss.C...

Background: Hypogonadotropic hypogonadism in apubertal males is commonly due to constitutional delay; permanent gonadotropin deficiency becomes more likely with older age at presentation, cryptorchidism and non-reproductive defect, e.g. anosmia. All forms of testosterone induce pubertal development, though short-acting IM preparations are associated with extraphysiological excursions of serum testosterone and are increasingly unavailable. Long-acting testosterone undecanoate I...

Aim: To determine whether cases of hypocalcaemia presenting via an emergency medical admissions unit (EAU) are appropriately investigated.Background: Hypocalcaemia is a potentially life threatening abnormality, with a prevalence of 18% among hospital inpatients.1,2 Risk factors include vitamin D deficiency, renal disease, hypoparathyroidism (typically post-neck surgery) and hypomagnesaemia. A reasonable investigational dataset comprises U+Es a...

41 year old male presented in 1992 with 2 years history of blurring of vision, headaches, dizzy spells. Had Right supratemporal visual field defect, pituitary MRI which showed cystic pituitary lesion. Had TSS in May 1992 and histology showed Rathkes pouch cyst. Post operatively developed DI and started on DDAVP.SST,TRH and GnRH tests were normal. Persisted retro orbital head aches, developed nasal and temporal field loss. MRI in Sept 1992 showed large intrasellar recurrence of...

Background: Enzalutamide is a next-generation androgen receptor (AR) antagonist, used as a daily oral agent, in the treatment of castration-resistant prostate cancer. Its suppression of 11β-hydroxysteroid dehydrogenase-2 enzyme has been reported in the literature, leading to hypertension through a relative increase in cortisol concentration at the level of the mineralocorticoid receptors. Enzalutamide is also known to be a potent inducer of drug metabolising enzymes (cyto...

Background: Optimization of sex hormone replacement therapy (SHRT) is essential in long-term management of patients with hypogonadism. However, approaches to formulations of therapy, dose change (if any), monitoring of adequacy of therapy and safety are not standardised.Objectives: The survey aimed to establish the approach to management of SHRT for male and female hypogonadism.Methods: Online survey, live for 4 weeks (1/11/2021) d...

Introduction: Hypercalcaemia diagnosed in hospital setting is most commonly PTH-independent and malignancy related, whilst hypercalcaemia discovered in community setting is commonly secondary to Primary Hyperparathyroidism (PHPT). Other rare causes include granulomatous diseases such as sarcoidosis and familial hypocalciuric hypercalcaemia (FHH).Case Summary: A 73-year-old male with a background of hypertension and chronic kidney disease stage 3 was foun...

Background: Congenital adrenal hyperplasia (CAH) is the commonest genetic endocrine disorder, affecting 1 in 18 000 UK births. The 2010 CaHASE Study identified a myriad of health problems associated with CAH and its treatment, and a lack of consensus on treatment strategies in adults. Endocrine Society guidelines (2010, revised 2018) have since been published to support management. As one of the original CaHASE centres, we have audited our recent practice against these new sta...

Background and aims: Electrolyte imbalance is common among hospital inpatients, reflecting severity of underlying illness, but also independently contributing to excess morbidity and mortality. However, studies have largely been retrospective, with incomplete data capture. We prospectively evaluated the prevalence of major Na and Ca disorders among inpatients at the Newcastle-upon-Tyne Hospitals.Method: With approval of the Information Guardian, we used ...